Loss of cellular immune reactivity during acutePlasmodium falciparummalaria

Loss of o-phthaldialdehyde reactivity during storage of infant cereals.

A fluorimetric method was used to determine the o-phthaldialdehyde (OPA) reactivity of amino groups for the assessment of non-enzymatic browning reactions in products with a prolonged shelf-life. The studies were conducted in four commercial infant cereals: wheat-based '7-cereals' and '8-cereals', and gluten-free 'rice cereal' and 'rice-corn cereal'. The cereals were monitored at 28 degrees C f...

review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis

cellular and molecular pathways link thrombosis and innate immune system during sepsis. extrinsic pathway activation of protease thrombin through fviia and tissue factor (tf) in sepsis help activate its endothelial cell (ec) membrane protease activated receptor 1 (par-1). thrombin adjusts the ec cycle through activation of g proteins (g12/13), and later through rho gefs (guanine nucleotide exch...

Soothing touch of CD31 protects endothelium during cellular immune responses.

CD31 is a member of the Ig gene superfamily that is present on the surface of platelets and all leukocytes (1). CD31 is also highly expressed on endothelial cells, where it represents a major constituent of the intercellular junction (1). Based on this cellular distribution and similarities in the cDNA sequence coding for extracellular domains, CD31 has initially been considered as a member “am...

Antigen kinetics determines immune reactivity.

A current paradigm in immunology is that the strength of T cell responses is governed by antigen dose, localization, and costimulatory signals. This study investigates the influence of antigen kinetics on CD8 T cell responses in mice. A fixed cumulative antigen dose was administered by different schedules to produce distinct dose-kinetics. Antigenic stimulation increasing exponentially over day...

Humoral and Cellular Cross-Reactivity